Paralysis (SCI & MS)

Summary
Background: Regenerative therapy by autologous stem cell implantation may benefit patients with traumatic spinal cord (SCI). Aims: The aim of this study was to analyze the safety and efficacy of autologous stem cell implantation for traumatic SCI and BI in a clinical setting. Patients and Methods: Eighty one patients (74 with SCI), age between 18 and 65 (median 43), were included in the study. Fifteen to 40×106 CD34+ cells per patient were implanted. Διάβασε περισσότερα »

A pressure ulcer is an area of skin that breaks down when you stay in one position for too long without shifting your weight. This often happens if you use a wheelchair or you are bedridden, even for a short period of time (for example, after surgery or an injury). The constant pressure against the skin reduces the blood supply to that area, and the affected tissue dies.
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According to a clinical study conducted at the REHAB in Basel, Switzerland, THC was effective in reducing spasticity in 25 patients with spinal cord injury. In three study phases patients received oral THC, rectal THC-hemisuccinate (THC-HS) and/or placebo, each for six weeks. Originally, it was planned to start with an open phase with oral THC followed by an open phase with rectal THC-HS and then a three-way crossover placebo-controlled phase with oral THC and rectal THC-HS. Due to logistical problems with the import of THC- HS Phase 2 had to be stopped after inclusion of seven patients. Phase 3 was changed to a parallel study with oral THC and placebo.
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BRYAN – Shonnie Moore of College Station, paralyzed in a July 2005 traffic accident, has had to learn how to eat, bathe and live all over again through physical therapy.
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Pasadena, CA (PRWEB) — The illumination of the human genome has opened the door to a vast range of medical therapies. The promise of drugs and interventions tuned to the individual patient’s genetics holds persuasive advantage over the one-size-fits-all generic remedies we count on today. Further progress in this booming field of molecular medicine, however, relies in part on continuing stem cell research using human embryos. Although the cells themselves are microscopic, their use in medical research has become one of the biggest current moral issues in society.
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The Associated Press

September 21, 2006

Swiss biotech firm Serono SA, which earlier Thursday agreed to sell a majority stake in the company to German drugmaker Merck KGaA for $13.31 billion, said its oral cladribine treatment for multiple sclerosis has received ‘fast-track’ status from the U.S. Food and Drug Administration.

This designation covers patients with relapsing forms of multiple sclerosis.

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VANCOUVER — Researchers at the B.C. Institute of Technology are trying to help paraplegics and quadriplegics with an everyday problem that gets ignored in the high-profile quest to regenerate damaged spinal cords: How to help people have a satisfactory sex life.
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Sept. 13, 2006 — Patients with relapsing multiple sclerosis responded well to the experimental drug fingolimod, giving new hope for an oral MS drug, new research shows.
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Professor Greg Whyte warns too much exercise does ‘more harm than good’

The academic who trained David Walliams for his Channel swim has warned fitness fanatics that too much exercise can kill.
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As a physical therapy student in the 1970s, Thomas Holtackers learned to help people overcome injuries that interfered with their daily activities. When Holtackers was diagnosed with multiple sclerosis (MS), he supplemented his physical therapy work with insight gained from personal experience. These days, a retired Holtackers actively encourages positive thinking to help people with disabilities meet the challenges of daily life.
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“The body’s spinal cord is lik e a super highway of nerves. When an injury occurs, the body’s policing defenses put up a roadblock in the form of a scar to prevent further injury, but it stops all neural traffic from moving forward.”
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Skin Deep: Imaging Technologies May Detect Pressure Ulcers And Deep-tissue Injuries That Healthcare Workers May Miss…
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Nine out of ten men fitted with a penile prosthesis were able to have sexual intercourse and eight out of ten were satisfied with the overall results.
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New treatments derived from embryonic stem cells could help paralyzed patients. (Credit: Science Photo Library)
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I have a spinal cord injury and have used a wheelchair for nearly 32 years. I am healthy, happy and lead a very full and rewarding life. I am part of the disability pride and independent living movement. I am happily married, work full time, attend law school, pay taxes and vote. I do not consider my life a “tragedy” and I do not consider myself to be “suffering” from anything.
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Researchers at the University of Michigan Medical School and Johns Hopkins University have developed a treatment that helps animals with traumatic spinal cord injuries grow new nerve fibers.
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LISBON, July 21, 2006 (LifeSiteNews.com) – A team of researchers from Hospital de Egas, Lisbon, Portugal and Wayne State University Medical School in Michigan, USA, have shown that stem cells taken from the olfactory mucosa can be used successfully to treat spinal cord injuries, even years after the injury occurred.
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WEDNESDAY, July 26 (HealthDay News) – Patients who experience a dangerous dip in heart rate after spinal cord injury may need heart-pacing therapy, researchers report.
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NEW YORK (Reuters Health) – Injections of Botox, or botulinum toxin-type A, appear useful in the treatment of drug-resistant urinary incontinence due to traumatic spinal cord injury, UK researchers report.
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Prosecutors are taking a firm line on the supply of cannabis for pain relief to people with chronically painful conditions such as multiple sclerosis, despite the downgrading of the drug from class B to class C.
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In tests on rats, researchers at Johns Hopkins and the University of Michigan have developed a treatment that helps spinal cord nerves regrow after injury.
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What is the urinary tract?

The urinary tract or system consists of the kidneys, ureters, bladder, and urethra. The key players in the system are the kidneys, a pair of purplish-brown organs located below the ribs toward the middle of the back. The kidneys remove liquid waste from the blood in the form of urine, keep a stable balance of salts and other substances in the blood, and produce a hormone that aids the formation of red blood cells. Narrow tubes called ureters carry urine from the kidneys to the bladder, a triangle-shaped chamber in the lower abdomen. Urine is stored in the bladder and emptied through the urethra.
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TUESDAY, July 18 (HealthDay News) — A treatment that promotes the regrowth of injured spinal cord nerves has proven successful in rats, U.S. researchers report.
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Multiple Sclerosis patients who receive a brief course of Mitoxantrone, and then Cupaxone, experience a reduced replase rate of 90%, according to a five-year study carried out at The Walton Centre for Neurology, Liverpool, UK. A further ten controlled studies are being launched at 10 centres in the UK. A reduced relapse rate of 90% means the difference between being bedridden and holding down a job and actively raising a family for many MS patients.
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Patients with recurring problems with the heart slowing or stopping after a neck injury damages their cervical spinal cord may need aggressive therapy to avoid further cardiovascular problems and even death, Medical College of Georgia researchers say.
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Transplanting human embryonic stem cells does not cause harm and can be used as a therapeutic strategy for the treatment of acute spinal cord injury, according to a recent study by UC Irvine researchers.
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Researchers at the University of Michigan Medical School and Johns Hopkins University have developed a treatment that helps animals with traumatic spinal cord injuries grow new nerve fibers.
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Transplanting human embryonic stem cells does not cause harm and can be used as a therapeutic strategy for the treatment of acute spinal cord injury, according to a recent study by UC Irvine researchers.
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AUSTIN, Texas (AP) — A new high-tech version of the tooth fairy now exists, but some scientists are not ready to bite.
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In tests on rats, researchers at Johns Hopkins and the University of Michigan have developed a treatment that helps spinal cord nerves regrow after injury. The findings will be published in the July 18 issue of the Proceedings of the National Academy of Sciences. The study has implications for treating people who may face amputation of an arm after a violent injury in which nerves are wrenched from the spinal cord. The new treatment currently is under study for other types of traumatic spinal cord injury.
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Transplanting human embryonic stem cells does not cause harm and can be used as a therapeutic strategy for the treatment of acute spinal cord injury, according to a recent study by UC Irvine researchers.
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With the aid of electrodes implanted in his brain, a man paralyzed from the neck down was able to perform certain everyday activities — move a computer cursor, open e-mail, turn on a TV set — merely by imagining them.
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The President’s stand could slow research, but scientific ingenuity is cooking up new breakthroughs…
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Scientists have made stunning progress helping paralyzed rats and mice walk again by injecting them with stem cells. Now researchers at Geron of Menlo Park want to take the next step — in people.
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CHICAGO — Spinal cord injuries are among the toughest conditions doctors encounter. So far, science has little to offer paralyzed patients.
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Spinal cord injuries are among the toughest to heal but thanks to new technology, not all those injuries are permanent today.
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It’s called electrical stimulation exercise therapy, and small but tantalizing studies suggest that this intense rehab just might help restore some function to people with spinal cord injuries, even if they were paralyzed long ago.
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A Supreme Court decision on Monday seems to make equal education harder to obtain for special needs students.
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Multiple sclerosis patients in the UK are to be able to get a cannabis-based pain-relief drug from their doctor for the first time, it has been announced.
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Newswise — Clinical research data published in the December issue of Multiple Sclerosis provided evidence that COPAXONE® (glatiramer acetate injection) may offer protection from axonal injury and induced neuronal metabolic recovery in patients with relapsing remitting multiple sclerosis (RRMS).
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TRAVERSE CITY – Laura Barber says she’s convinced good will come from an approved city ordinance instructing police to go easy on those who use marijuana for medical purposes, although critics dismiss it as a worthless gesture.
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Multiple sclerosis is a debilitating disease. This woman was diagnosed 10 years ago.
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Aerobic exercise is thought to help persons with multiple sclerosis fight fatigue, the most common symptom of the disease. Yet as the body heats up during exercise, it compromises the ability of people with MS to exercise and they become fatigued sooner.
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Scientists have made stunning progress helping paralyzed rats and mice walk again by injecting them with stem cells. Now researchers at Geron of Menlo Park want to take the next step — in people.
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PARIS, FRANCE — October 31, 2005 — Cyberknife image-guided radiosurgery is effective and generally safe for managing spinal metastases, according to data announced on October 31st at the 13th Annual Meeting of the European Cancer Conference (ECCO).
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IRVINE, Calif., Nov. 1, 2005 – A new, easily manufactured microfluidic chamber will allow scientists to examine axons in living nerve cells and may lead to a better understanding of neurodegenerative disorders such as Alzheimer’s disease and may be used to screen drugs to overcome spinal cord injuries, according to researchers in The Henry Samueli School of Engineering at the University of California, Irvine.
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An international team of researchers including Harvard scientists published last week a catalog of common human genetic variants—known as the HapMap—that they hope will lead to a better understanding of the causes of genetically-based diseases such as diabetes, multiple sclerosis, and bipolar disorder.
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J.P. Morgan Securities upgraded shares of Biogen Idec (nasdaq: BIIB – news – people ) to “overweight” from “neutral” and said the odds are high the company’s multiple sclerosis drug will return to the market before then end of 2006, based on discussions with neurologists.
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Multiple sclerosis can range from relatively mild to somewhat disabling to devastating. Many researchers believe MS is an
autoimmune disease — meaning the body’s immune system attacks its own tissues.
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A substance made by immune cells may play a key role in the development of multiple sclerosis, research suggests.
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